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In mouse models of type 2 diabetes induced by a high‑fat diet and streptozotocin, 4 weeks of 5‑amino‑1mq injection reduced fasting blood glucose by 25%–30%, increased insulin secretion by over 20%, and significantly decreased β‑cell apoptosis

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NAD+ and SAM accumulation Nicotinamide that is not methylated stays available to nicotinamide phosphoribosyltransferase and re-enters the NAD+ salvage pathway